Imcivree (Setmelanotide)

Imcivree (Setmelanotide)

Imcivree (Setmelanotide) attaches to a receptor in the brain called melanocortin receptor 4, which promotes a feeling of fullness after eating.

How Is Setmelanotide Used?

Imcivree can only be obtained with a prescription and treatment should be prescribed and supervised by a doctor with expertise in treating obesity caused by genetic conditions.

Imcivree is given once a day as an injection under the skin. The dose depends on the condition being treated, the effect of the treatment and how well it is tolerated. After being trained, patients or carers can inject the medicine themselves.

How Does Setmelanotide Work?

Obesity is a complex condition that may be driven by a combination of genetic, behavioural, metabolic or lifestyle factors. Obesity caused due to POMC, PCSK1 or LEPR deficiency is an ultra-rare disease.

Syndromic obesity is linked to a variety of phenotypes, the most common of which are BBS and Prader Willi syndrome, both of which cause severe obesity by impairing the MC4 receptor pathway. From early in life, children with the condition exhibit an increased appetite, endocrine issues, red hair, and pale skin colour.

Side Effects of Imcivree : injection site reactions, darkening of the skin, nausea, headache, diarrhea.